In Observance of U.S. Holiday, Memorial Day, Agilent Cross Lab/ iLab Operations Software Support Help Desk will be closed during U.S. hours on Monday May 27th, 2019. We will resume regular U.S. support hours on Tuesday May 28th, 2019. EU and APAC Support will remain open during this time. For urgent matters, please add "Urgent" to the ticket/ email subject or press "1", when prompted, to escalate a call on the iLab Support phone and we will prioritize those requests first.

MDACC Advanced Microscopy Core

Overview of Services


Super-Resolution Structured Illumination Microscopy (SIM)

Equipment: OMX Blaze V4 Microscope

  • Spatial resolution ~120 nm (XY), ~300 nm (Z)
  • 3-D high impact imaging of cellular structures


Super-Resolution Localization Microscopy (STORM/PALM/GSD)

Equipment: Vutara SR-200 Biplane Microscope (3-D) and OMX Blaze V4 Microscope (2-D)

  • Spatial resolution ~20 nm (XY), ~ 60 nm (Z)
  • Molecular studies of subcellular structures at the highest optical resolution available


Total Internal Reflection Microscopy (TIRF)

Equipment: OMX Blaze V4 Microscope  

  • Spatial resolution ~250 nm (XY), ~ 100 nm (Z thickness)
  • Studies of live cell membrane receptor-ligand interactions, cellular adhesion, endo and exocytosis, etc.)


Förster/Fluorescence Resonance Energy Transfer (FRET)

Equipment: OMX Blaze V4 Microscope

  • 1-10 nm molecular distance sensitivity
  • Static and dynamic mapping of molecular interactions inside cells
  • ‘Cyan/Yellow’, ‘Green/Red’ and ‘Red/Far Red’ donor/acceptor compatibility

Sensitized Emission (3-Cube) Method or Photobleaching Method


Laser Scanning Confocal Microscopy

Equipment: Leica SP8 Confocal Microscope with fast scanners, spectral detectors and live cell enclosure

  • Spatial resolution ~250 nm (XY), ~600 nm (Z)
  • Channel unmixing by spectral fingerprinting
  • Fast imaging of live or fixed cells and tissue by resonant scanning and photon-counting HyD detectors
  • FRAP (Fluorescence Recovery After Photobleaching) for molecule dynamics
  • Automated image stitching for large specimens and 3-D Assay imaging in multi-well plates

3-D Image Analysis and Visualization

IMARIS Software

  • Adaptive thresholding with hundreds of morphological measurements
  • Spatiotemporal tracking

3-D video design with rotations, fly-through, zooming and time-lapse visualization



Tomasz Zal|Core Director

M. Anna Zal|Core Manager


Location and hours of operation

Hours      Location

Monday - Friday 8:00 am-5:00 pm 

     7455 Fannin
     Houston, TX 77054

Links and Resources

  1. MD Anderson Advanced Microscopy Core


Name Role Phone Email Location
M. Anna Zal, M.Sc.
7455 Fannin Houston, TX 77054